The more we learn
about superhormones such as progesterone, the more we learn about their amazing
potential. Progesterone is no exception.
In this regard, some of the most exciting work on progesterone is being
done in France by a group headed by Dr. Etienne Emile Bau lieu, who is also a
pioneer in DHEA research. Recently, Dr. Baulieu’s team at the University of
Paris found evidence that progesterone may be an effective treatment for certain
nerve diseases, including multiple sclerosis.
It has long been
known that progesterone is produced in the central nervous system and that it
plays a role in helping nerves communicate with each other. That is why
progesterone, like other superhormones such as estrogen and testosterone, are
related to neurotransmitters, that is, substances that carry messages from
nerve to nerve and help run the vast communication network within the body The
French researchers found that progesterone is produced in yet another site in
the nervous system, in special cells called Schwann cells. These are found in the
peripheral nervous system, the collection of nerves that branch off from the
central nervous system. In the peripheral nervous system, progesterone may play
a previously undetected role in the maintenance of nerves, i.e., touch and
motor function.
The French
researchers discovered that progesterone promotes the formation of the myelin
sheath, the fatty substance that surrounds and protects nerve fibers. The
myelin sheath is, to nerves what plastic, insulation is to electrical wires.
They, learned about progesterone’s role in myelin formation by injuring nerves
in the legs of male mice and monitoring the mechanism in the body that repaired
the injury. These researchers noted that concentrations of progesterone were,
significantly higher near the damaged nerves than in the blood, suggesting that
progesterone plays a role in the healing process. To test this theory, the
researchers added supplemental progesterone near the damaged nerves and then
noticed that there was a significant increase in the thickness of new myelin
sheaths. When researchers administered a drug that blocked the action of
progesterone, they noted that the thickness of the new myelin sheaths was
decreased. Based on these experiments, it appears as though progesterone does
indeed play a role in myelin production and in repairing nerve injuries.
The reason
researchers are so excited about progesterone’s newly discovered role in myelin
formation is that several serious diseases can occur when myelin production is
impaired, leaving the nerve tissues exposed. In fact, in multiple sclerosis, a
disease of the central nervous system, the loss of myelin results in a
breakdown of the nerve signaling system throughout the body. Symptoms of
multiple sclerosis include muscle weakness or paralysis, vision problems, and
lack of coordination. To date there is no cure and there are few effective
treatments for multiple sclerosis. What is so exiting about the discovery of
progesterone’s role in myelin formation is that it may one day lead to a
treatment for this disease and similar myelin deficiency diseases.
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