maandag 2 april 2012

Qlaira, een nieuwe, bio-identieke anticonceptiepil?

Qlaira, een nieuwe en zogenaamd “natuurlijke” anticonceptiepil, is goeggekeurd voor gebruik op de Europese markt. Mensen, laat je niet misleiden! Deze pil bevat een BIJNA lichaamsidentiek oestrogeen en een synthetische progestin dat potentieel gevaarlijke bijwerkingen heeft.

Qlaira Birth Control Pill
Truthiness in Advertising: Is QlairaReally a "Natural" Birth Control Pill?
New oral contraceptive, Qlaira is being marketed as "body-identical" but a closer look proves otherwise.
The headline of the "consumer media" press release from Bayer Healthcare says, "Natural hormone inspires new contraceptive pill."
Really?! I thought. This could be exciting! But of course it was not to be.
Qlaira, a new oral contraceptive approved for use in Europe is being marketed as a "natural" contraceptive because it contains a "body-identical" estrogen, another way of saying bioidentical. Bayer Schering Pharma, the manufacturer of Qlaira, hasn't made the actual leap onto the bioidentical bandwagon, but they apparently want to tap that market via misleading marketing. In the spirit of truthiness, they want to be natural but it just ain't so. Qlaira contains an almost-bioidentical estrogen and a very syntheticnot body-identical progestin. It's like saying that a Twinkie is natural because it contains high fructose corn syrup.
Estradiol Valerate
The estrogen in Qlaira is estradiol valerate which is close to being bioidentical, or body-identical. Once the body removes the "valerate" part of the molecule, it becomes estradiol, a bioidentical estrogen.
The other hormone in Qlaira is dienogest, a progestin, which is a progesterone that has been tweaked in the laboratory to create a decidedlynot body-identical hormone. Or to put it another way, dienogest is not found anywhere in nature - it is man-made.
Dienogest is a progestin with antiandrogenic effects, meaning that it reduces testosterone levels. It also has anti-mineralocorticoid effects, which means it can reduce the effects of bloating (water retention) often caused by excess estrogens. Like most of the progestins found in oral contraceptives, dienogest increases many of the blood factors that increase the risk of having a stroke.
Dienogest blocks the formation of ovarian follicles, which means that women using it do not ovulate, and therefore do not produce hormones, including estrogen, progesterone or testosterone. Thus, a woman taking Qlaira will have little or no testosterone (and possibly no sex drive as a result), no progesterone, and some estradiol. The dienogest will have some progesterone-like effects, but will not have the full spectrum of natural progesterone effects.
A German study examining the effect of high doses of dienogest on endometriosis found the women taking it had a significant reduction in breast size. This doesn't necessarily mean that Qlaira will reduce breast size.
Qlaira Marketing
Bayer is so far focusing its marketing on the estradiol component of Qlaira, which is unique. It is the first oral contraceptive to use an essentially natural estrogen. However, pretending that this makes it a "natural" contraceptive by ignoring the dienogest is misleading. It's likely that if this product isn't already in the U.S. FDA pipeline awaiting approval (possibly under a different name), it will be, and the marketing will undoubtedly follow the same twisted path. Buyer be aware.

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